General
Preferred name
JNJ-78386204
Synonyms
JNJ6204 ()
JNJ 6204 ()
JNJ-6204 ()
JNJ_6204 ()
P&D ID
PD195620
CAS
2765264-50-2
Tags
available
free of charge
probe
Probe info
Probe type
experimental probe
Probe sources
High-quality chemical probes
Open Science Probes
Probe targets
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION JNJ-6204 is a dual casein kinase 1 (CK1) δ/ε inhibitor . The compound is deuterated to improve its metabolic stability. (GtoPdb)
DESCRIPTION JNJ-6204 is a dual inhibitor of CSNK1D (IC50 = 2.3 nM) and CSNK1E (IC50 = 137 nM). (TargetMol Bioactive Compound Library)
Compound Sets
6
EUbOPEN Chemogenomics Library
CHEMBL5081774
Guide to Pharmacology
13345
High-quality chemical probes
PD195620
Open Science Probes
JNJ-6204
Other bioactive compounds
TargetMol Bioactive Compound Library
T69522
External IDs
7
Properties
(calculated by RDKit )
Molecular Weight
364.14
Hydrogen Bond Acceptors
6
Hydrogen Bond Donors
1
Rotatable Bonds
2
Ring Count
5
Aromatic Ring Count
4
cLogP
3.33
TPSA
81.51
Fraction CSP3
0.26
Chiral centers
0.0
Largest ring
6.0
QED
0.59
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Target
c-Fms
CSNK1D, CSNK1E
Pathway
Tyrosine Kinase/Adaptors
Control name
JNJ-0293
Recommended Cell Concentration
1 uM
Source data